Corneal juvenile xanthogranuloma in a 4-month-old child.

Juvenile xanthogranuloma (JXG) is a benign histiocytic disease of uncertain pathogenesis that usually appears as a cutaneous lesion(s) in the head and neck region of young children. Diagnosis is based on histological examination that shows a nodular, dense infiltrate of polygonal or spindled mononuclear cells with moderate amounts of cytoplasm and scattered Touton giant cells. Juvenile xanthogranulomas are typically positive for CD68 and factor XIIIa immunostains and are negative for CD1a and S100 protein; this information is helpful in differentiating JXG from other histiocytic proliferations. We present the case of a 4-month-old child with corneal JXG.